Over the course of the series, certain lyrics have been changed, including an entire verse, originally sung by Kenny McCormick, sung by Timmy Burch in the Season Six intro due to Kenny's temporary death in the Season Five episode "Kenny Dies". From the episode "Fourth Grade", to "Kenny Dies", a hip-hop version of the song was used, which was remixed by Paul Robb. Afterwards, they used a bluegrass remix of the song until mid-Season Ten, where the original song was remixed with "Whamola" by Les Claypool and his group, The Frog Brigade, from their album, Purple Onion.
When Comedy Central started airing reruns of older episodes, the opening theme was back to the way it was during Season Three, with the addition of several recent characters.
For the special "Goth Kids 3: Dawn of the Posers", a new theme song was made specifically for the episode. The lyrics were altered to fit the personality of the characters.
From Season Seventeen and onwards, a 3D computer-animated version of the intro is used, and it consists of the bus driver driving past various South Park locations as the four main boys sing their lines, resembling the Season One-Four intro in many respects, with the exception of the 3D animation and "Whamola" instrumental.
In the episode “Sons A Witches”, the theme song was altered with many Halloween-themed elements added.
莱斯·克莱普： I'm goin' down to South Park, gonna have myself a time. 凯尔 + 斯坦： Friendly faces everywhere, humble folks without temptation! 莱斯·克莱普： I'm goin' down to South Park, gonna leave my woes behind. 卡特曼： Ample parking day or night, people spouting: "HOWDY, NEIGHBOR!" 莱斯·克莱普： I'm headin' on up to South Park, gonna see if I can't unwind. 肯尼 或 提米: 参见以下 莱斯·克莱普： So come on down to South Park, and meet some friends of mine.
肯尼（试播集）：Our town is bigger dammit, right down to the little granite. 肯尼（第一二季）：I like girls with big fat titties, I like girls with deep vaginas! 肯尼（第三至五季；第一二季高清版）：Me, I got a 10-inch penis, use your mouth if you wanna clean it. 提米（第六季）：Timmy, Timmy, Timmy, Timmy, Timmy, Timmy, livin' a lie TIMMY! 肯尼（第七至十季）：Someday I'll be old enough to stick my dick up Britney's butt! 肯尼（第十季第八集至今）：I like fucking silly bitches and I know my penis likes it. (Occassionally misinterpreted as Kenny saying "Welcome to South Park" twice)
These were never censored because it was already difficult to make out.
歌手： Goin' down to South Park
Gonna have myself a time 迈克尔和亨利埃塔： Death and sadness everywhere
Loneliness and degradation 歌手： Goin' down to South Park
Gonna take my woes with me 皮特： Nightmares every night
Posers spouting "Let's go shopping". 歌手： Heading out to South Park
'Cause I cannot unwind 弗尔科： I Like spiders, loss and rain
I'm only happy when I'm in pain 歌手： So I'm goin' down to South Park... to die! (echoes at the word "die")