Premise Running Thin appeared in the Season Seven episode, "Red Man's Greed".
His father, Chief Runs With Premise, owns the Three Feathers Casino and wants to build a super-highway through South Park. South Park stands up to the Native Americans, who intentionally infect them with S.A.R.S..
Chief Runs With Premise later learns that his son shared a drink with one of the infected Chinese men, and contracted the disease. Premise Running Thin is later cured with the "middle-class white way" cure for S.A.R.S., which consists of warm soup and Sprite.
Premise Running Thin is a Native American boy with long black hair. He wears a red and yellow striped headband with a blue feather. He also wears a light blue shirt with a dark blue and white diamond pattern on it.