Stan is then told that South Park might have a chance of surviving the deadly smug cloud, but San Francisco doesn't have a snowball's chance in hell. The episode ends with a total destruction of San Francisco and severe damage to South Park. Before it was destroyed, it was revealed that most children in San Francisco do drugs, as they are not capable of dealing with their parent's excessive smugness.
San Francisco is also mentioned by Cartman in the episode “象猪交配”, Cartman says to 凯尔·布罗夫洛夫斯基 "Why don't you go back to San Francisco with the rest of the Jews!"
San Francisco was again mentioned in “鲸鱼婊卫战”, suggesting the city had been rebuilt.
In the song “You and Cthulhu” played in “神秘侠崛起” with 埃里克·卡特曼 and Cthulhu flying through the air, Cthulhu destroys San Francisco, along with hippies, and a synagogue; everything Cartman hates.