The show opens with a completely new theme song dedicated to the PC babies, who are the extremely politically correct quintuplet children of South Park Elementary principal PC Principal and vice-principal Strong Woman. At South Park Elementary, PC Principal announces that Strong Woman will be competing in a STRONGWOMAN Competition where she is the reigning champion. She encourages the girls of the school to be more active in school sports and activities.
Fourth-graders Cartman, Stan, Butters, Clyde Donovan and Scott Malkinson are in a gaming club named Dice Studz playing Dungeons & Dragons when they are interrupted by school counselor Mr. Mackey who brings in Tammy Nelson and Nichole Daniels who wish to join. Although the boys are hesitant to let the girls play, the girls immediately display a knowledge of the game that stuns the boys. Cartman, Butters and Scott complain to Mackey about the girls in their club but they are dismissed. The boys collectively decide to switch their games to tabletop miniature games to make their games to difficult for the girls to play, but the girls come in immediately prepared for the game, and Stan becomes more comfortable with the girls' presence. Cartman, Butters and Scott plead to the United States Congress to return their club to the way that it was. In response, the girls start up their own gaming club named Board Girls which is hugely popular. The boys are fascinated by their new club, but Mackey kicks them out of the club as a new rule in school no longer allows boys in girls clubs, a direct result of the boys pleas to Congress.
At the STRONGWOMAN Competition, Strong Woman is interviewed and told that there is a new transgender athlete competing named Heather Swanson. When Swanson is introduced, it is revealed that she is an extremely muscular, bearded athlete who is a parody of "Macho Man" Randy Savage" who only started identifying as a woman a few weeks ago. Swanson easily defeats the other competitors to win the contest, with Strong Woman finishing in second place. Swanson visits Strong Woman and PC Principal at their home to brag about her victory and gets into an argument with PC Principal, calling him a transphobe. Swanson has an interview on a sports talk show with multiple trophies and awards as she has won every women's sporting contest she has entered recently. She issues a challenge to Strong Woman, who is watching on television at home. Strong Woman reveals to PC Principal that she personally knows Swanson as her ex-boyfriend Blade Jaggart, and the reason for Swanson's attacks on Strong Woman is due to Swanson feeling that he was beaten by a woman when they broke up. As Swanson has an interview celebrating her success in mixed martial arts, PC Principal interrupts her on set causing another argument. In the heat of the moment, PC Principal shoves Swanson, and she dives through a table, breaking it.
PC Principal's reputation is damaged from his actions, and Strong Woman consoles him in a park as Principal does not want to face his babies due to his actions. Principal decides to invite Swanson to South Park Elementary as a motivational speaker in an attempt to make up for his actions. As Swanson brags about her ability to beat any woman at any contest, the girls from Board Girls retort that she would be unable to beat any of them in some of their favorite games. Swanson accepts their challenge and is repeatedly defeated by the Board Girls in various games. Swanson leaves in anger as Cartman invites Swanson to make their own club instead. PC Principal returns home and finds that his children have accepted his actions as they simply do not care.