In "Chef's Chocolate Salty Balls", Tom Hanks stars in a film based on Mr. Hankey and a parody of Philadelphia called Mr. Hankey and Me, alongside a monkey that plays Mr. Hankey. While watching the film, Eric Cartman questions the choice of casting Hanks in the film, saying that "Tom Hanks can't act his way out of a nutsack".
Hanks makes his second physical appearance in the Season Eighteen episode "HappyHolograms", where he appears as one of the celebrity guests on the Washington Redskins: Go Fuck Yourself Holiday Special.
In "Chef's Chocolate Salty Balls", Tom Hanks has short black hair, black eyebrows, and a slight cleft chin. He wears a cyan hospital gown with a white trim. He also appears as a live-action photograph on some T-shirts that Cartman sells.
In "HappyHolograms", Hanks has a similar appearance, but with more detailed facial features as well as shorter hair and thicker eyebrows. He wears a dark green suit over a red shirt, a white bow tie, dark green pants, and black shoes.