在超级英雄系列，混沌教授没有表现出什么电磁能量波的超能力（哪怕这些都是假装的），这和他在兵器好时光的超级反派形象很不同，他接着被神秘侠在战斗中打败，即使有无序将军帮助也没有效果。 Cartman, as the Coon, seeks Chaos's assistance in order to figure out the identity of Mysterion. He then allies with Professor Chaos and bullies Chaos into threatening to blow up a hospital if Mysterion doesn't reveal his identity. When the Coon leaves, Mysterion confronts Chaos, and Disarray flees. Disarray soon rejoins the fight and flees again in their brawl against Mysterion. Then, the Coon comes to finish off Chaos by slashing him, thus making Chaos run away home. He later encourages Mysterion to reveal his identity otherwise crime can ensue.
In the later episodes of the Superheroes Arc, Chaos is only seen inside a holding cell at the Coon and Friends Headquarters as a punishment for his misdeeds, though it isn't seen what his deeds were. At the end of "Coon vs. Coon & Friends", The Coon is also in the same cell as Chaos after Cthulhu was defeated by Mint Berry Crunch.
Professor Chaos returns in the Season Twenty-One episode, "Franchise Prequel", where he creates fake Facebook posts about the Coon and Friends, ruining their reputation and keeping them from getting Netflix to greenlight their superhero franchise. He later hires a group of children to act as his minions, the Chaos Kids, and write even more fake posts about them. Butters then works with Mark Zuckerberg, who aids him in his plan, allowing all fake posts to surface, as the public blindly accepts each post as 'news'. However, Professor Chaos is thwarted when the Coon and Friends simultaneously clear their names, defeat Zuckerberg, and force him to shut down Facebook entirely.
A key to Professor chaos's Lair and Professor Chaos's costume can be found at Butters's House, the lair is located at the storage facility where you can befriend General Disarray, get several items, a Chinpokemon and roof access.
Butters 3rd ability is "Professor Chaos" which has butters turn into the anime style Professor Chaos, the player then spins a wheel to choose an ability these abilities include:
Chaos Cloak: Butters gives himself and Douchebag 9 shield.
Life Drain: Butters takes HP off enemies and restores his and Douchebag's.
Hammer Of Chaos: Butters calls down a huge hammer to damage all enemies stunning them.
Chaos Storm: Butters zaps 5 random targets with electricity.
Chaos Blast: Butters blasts all enemies with a laser resembling a Kamehameha from the Dragon Ball series, also butters uses this move against Nazi Zombie Death in the Nazi Zombie Kenny final boss fight.
The boys quickly suspect Professor Chaos as behind the attacks on the town and confront him in the "Butters' House" level, but after a brief discussion of his evil plan, he admits his real plan was far less devious and that he was not actually behind the attacks. Villains arrive and battle the five boys, but by the end Chaos shatters a testicle, and is taken to Hells Pass Hospital, the site of the next level, and afterwards is absent from the storyline.
He can be unlocked as a playable character if one has one of several unique special codes which were released with South Park: The Complete Thirteenth Season or are awarded online if you are very skilled at the game. His moveset is the "Sniper"-type used by Kenny McCormick, Craig Tucker and Pip Pirrup, with slow movement but heavy damage. His special ability is akin to that of Eric Cartman, reigning chaos and causing heavy damage to enemies all over the screen.
Professor Chaos was one of the main villains in South Park, employed by Mitch Conner, he was given 20000 dollars to keep the citizens from going into the U-stor-it. However, he had a greater plan, causing great havok to prove his worth to lead the crime wave. With the money he had, he transformed the entire facility into his giant lair, and he hired hundreds of minions to defend his property, purchased countless lego bricks to "lava" the town, he even built a huge "Mecha Minions Chaos Supreme" with missiles to fight the Coon and Friends.
With all the effort the Professor has made, he was still hopelessly defeated, and was brought back to the Coon Lair, locked in the cell previously held him for days. During the discussion, he revealed that the one who was paying was faceless, nameless, and simply wanted crime wave to go bigger.
He remained in custody until the next day, when the New Kid was about to infiltrate the Freedom Pals' base. Seizing a chance, Professor announced that he can help the New Kid get pass the security grid, the Coon objected, but Human Kite disagreed on that. Eventually, Professor Chaos got out of the cell, and decided to take his minions(hamsters) before going to infiltrate. He did retrieve his minions successfully, however, his dad, Steven Stotch, angrily spotted him, along with the New Kid. As Steven Stotch remain his anger against the Professor, he questioned the New Kid regarding their identity, the New Kid, on the other hand, didn't bother answering. As a result, the New Kid was grounded with Professor Chaos in Butter's room. While the Professor sat frustrated beside the bed, playing a harmonica, the New Kid looked around and figured out a way to "Haywire" the door's electrical systems.
混沌教授穿着锡纸做成的手套、头盔和鞋子，还披着一件绿色的披风。他的头盔没有顶，这使得他的金发能够露出来，还有一个红点在他的额头上Professor Chaos wears tinfoil gloves, helmet, boots and a green cape. His helmet has a red dot on the forehead. His helmet has no top, showing Butter's blonde hair. He has aluminum shoulder pads, connected by a chain that goes across his chest, shoulder to shoulder.
In "Good Times with Weapons", his appearance changes, such as becoming a muscular adult, his blonde hair becomes a blonde Mohawk, and boots change to feet wrapped in bandages, mimicking Muay Thai fighters who wear on bandages their feet. Professor Chaos mentions that his green cape is weaved with titanium. His eyes show no iris or pupils, like those of various anime characters in the episode, such as Bullrog's (Cartman) or Craig's.
混沌教授是一个疯狂科学家，目标就是Professor Chaos seems to be a mad-scientist-like villain whose goal is to bring chaos and disorder. In his debut episode, he was able to hack the Jumbotron screen at the stadium to announce that he's going to flood the world. This is the only exceptional act he has done as his immense powers in "Good Times with Weapons" are his imagination. He seems to be frustrated in "The Simpsons Already Did It" because every plan he came up with had already been done by the Simpsons but got over it after Chef and Garrison concluded that ideas have always been done by another, hence passed down.
His super powers are only featured in "Good Times with Weapons". When donning on his costume, he turns into a large muscular man, surrounded with an electromagnetic aura. When introducing himself to The Boys, he is able to hover above the ground and discharge bolts of lighting around him. His titanium cape is able to shield himself from special abilities cast by the boys. He is able jump up in the air and land on the ground causing a miniature earthquake. He is able to instantly cast a web, thus trapping people such as Stan and Kyle in the "Web of Holding". After Kenny's shuriken cuts Chaos's eye, Professor Chaos reverts into Butters. In the Superheroes Arc, there is no indication of the super powers he had in "Good Times with Weapons"
混沌教授用无情的效率将混沌外包出去，他的那些有些邪恶的计划得到实施，靠的是他的仓鼠小部下，混沌小孩们，还有墨西哥人。不过他并不是一个有证的教授。Professor Chaos outsources chaos with ruthless efficiency, relying on an army of hamster minions, Chaos Kids and Minions to execute his vaguely evil plans. Not an accredited professor. - In-game character description
Professor Chaos specializes in attack and disruption from a distance. His Chaos Blast is similar to Human Kite's eye lasers, while his Chaos Confuse-O-Tron works best against enemies in the thick of their own formation, where they can catch their allies with Shock and target them via Confuse; if nothing else, its long range lets him hit foes from a wide variety of angles. His Chaos Minion is an effective meat shield, being able to move around and inflict damage to draw enemy fire. His Ultimate ability is a powerful weapon against clusters of foes.
Professor Chaos is a strong buddy on higher difficulties, where Shock does more damage and turning enemies against each other with Confuse can become even more useful.
His field ability is Haywire, which allows the New Kid to fart a "Winged Minion" (a hamster with a tiny helmet and glider) at exposed wiring to deactivate certain devices.
- 他在英国漫画"The Dandy"，3565期，第七页中被抄袭了。一个年轻的读者把一张混沌博士的图片发送到了出版方的设计竞赛中，获奖者设计的超级英雄会在漫画中出现。他被描述成了一个成人超级英雄，而竞赛裁判似乎在搞出打新闻前并没有发现“混沌教授”是一个已经存在的角色。
- "Professor Chaos"
- "The Simpsons Already Did It"
- "My Future Self n' Me" - Butters shows his costume to Stan, which he mistakes as coming out as gay.
- "Krazy Kripples" - Seen at Christopher Reeve's evil meeting along with other villains.
- "I'm a Little Bit Country" (cameo) - Seen in the crowd with all the characters.
- "Good Times with Weapons"
- "Go God Go"
- "The Coon" - Teams up with the Coon to find out who Mysterion is.
- "Coon 2: Hindsight" - Seen in the Coon and Friends jail and ask for food.
- "Mysterion Rises" - Mysterion asks Chaos why he took photo of a hobo with a photo shopped of Captain Hindsight.
- "Coon vs. Coon & Friends" - Asks if he can see the "double rainbow" and The Coon (character) later joins him as his cellmate.
- "City Sushi" (mentioned only) - Nearly burned by Butters until Dr. Jauns interrupts him.
- "Butterballs" - Tries to teach his abusive grandmother a lesson but she had already adapted a new super-villain of her own.
- "Sarcastaball" (costume only)
- "Franchise Prequel" - Creates fake Facebook posts about the Coon and Friends to ruin their reputation. Hires an army of children, the Chaos Kids, to help him. Is later thwarted when the Coon and Friends force his business partner, Mark Zuckerberg, to take down Facebook.